We study molecular and medical aspects of various RNA viruses, especially hepatitis, hepaci and coronaviruses. One focus of our work is the study of viral transmission. To this end, we are developing new test systems to investigate the stability of viruses to environmental factors and disinfectants and to develop more efficient prevention strategies. to develop more efficient prevention strategies. In addition, we are investigating the cellular processes that control the virus replication in order to find new targets for antiviral agents in the long term. to find antiviral agents. For this purpose, we use a broad spectrum of methods from virology, infectious medicine, bioinformatics as well as cell and molecular biology.

Selected Publications

Hepacivirus Evolution

Behrendt et al. Hepatitis E virus is highly resistant to alcohol-based disinfectants. J Hepatol. 2022

Dies ist die Überschrift

Schuhenn et al. Differential interferon-α subtype induced immune signatures are associated with suppression of SARS-CoV-2 infection. PNAS. 2022

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Meister et al. Virucidal Efficacy of Different Oral Rinses Against Severe Acute Respiratory Syndrome Coronavirus 2. J Infect Dis. 2020

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Wißing et al. Virus-Host Cell Interplay during Hepatitis E Virus Infection. Trends Microbiol. 2021

Gömer et al. Intra-host analysis of hepaciviral glycoprotein evolution reveals signatures associated with viral persistence and clearance. Virus Evol. 2022

Kinast et al. C19orf66 is an interferon-induced inhibitor of HCV replication that restricts formation of the viral replication organelle. J Hepatol. 2020

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Pfaender et al. LY6E impairs coronavirus fusion and confers immune control of viral disease. Nat Microbiol. 2020

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Todt D et al. Robust hepatitis E virus infection and transcriptional response in human hepatocytes. PNAS. 2020