We study molecular and medical aspects of various RNA viruses, especially hepatitis, hepaci and coronaviruses. One focus of our work is the study of viral transmission. To this end, we are developing new test systems to investigate the stability of viruses to environmental factors and disinfectants and to develop more efficient prevention strategies. to develop more efficient prevention strategies. In addition, we are investigating the cellular processes that control the virus replication in order to find new targets for antiviral agents in the long term. to find antiviral agents. For this purpose, we use a broad spectrum of methods from virology, infectious medicine, bioinformatics as well as cell and molecular biology.
Gömer et al. Intra-host analysis of hepaciviral glycoprotein evolution reveals signatures associated with viral persistence and clearance. Virus Evol. 2022
Kinast et al. C19orf66 is an interferon-induced inhibitor of HCV replication that restricts formation of the viral replication organelle. J Hepatol. 2020
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Pfaender et al. LY6E impairs coronavirus fusion and confers immune control of viral disease. Nat Microbiol. 2020